Why Choose Us ?

The Fertility Clinic High Success Rates.fw

The Fertility Clinic Save evidence based treatment

The Fertility Clinic Indvidulised care

The Fertility Clinic One to One support

What is Infertility ?

Success Stories

Success Stories The Fertility Clinic

The Fertility Clinic Google

Do sperm-derived factors activate endometrial NK cells?

The potential role of paternal sperm derived white blood cells and soluble factors in activating non-pregnant endometrial NK cells

The potential role of paternal sperm derived white blood cells and soluble factors in activating non-pregnant endometrial NK cellsWhat is the purpose of this study?

The successful outcome of a pregnancy requires, amongst other things, that the placenta grows well so that it can supply the developing foetus. If placental growth is insufficient this can lead to a number of problems, for example babies that are small when born (intrauterine growth retardation) or high blood pressure and kidney problems in the mother (pre-eclampsia). The reason(s) why the placenta fails to develop in some pregnant women are poorly understood. However, recently it has been shown that certain cells in the pregnant womb, so called uterine NK cells, produce chemicals that help the development of blood vessels in the placenta. These uterine NK cells are present in very large numbers in the womb during a healthy pregnancy. However, we don’t know where these cells come from.

In the non-pregnant womb there is an accumulation of another type of NK cell, called the endometrial NK cell. While somewhat similar to the cells seen in pregnancy these endometrial NK cells do not support the development of the placental blood vessels. One theory suggests that these endometrial NK cells receive a “signal” during the very early stages of the pregnancy, and this changes them to uterine NK cells. While this is possible the nature of the “signal” initiating this shift is not known.

During sexual intercourse apart from the sperm, which is necessary for the fertilization of the egg, a number of the male partner’s white blood cells and various chemicals also enter the womb. This study aims to find out if either the white blood cells or some of the chemicals present in the sperm could turn endometrial NK cells to uterine NK cells.

Study subjects?

Women having laparoscopic sterilisation to provide a permanent method of contraception. Given that they have already had children, they have proved that the lining of their womb can support a pregnancy, and hence the lining would be deemed normal. We would therefore like to take a small sample of the cells from the lining of the womb whilst they are being sterilised, so that we can use it in this research project. We hope that by looking at the cells in a normal healthy fertile population, that we will be able to make comparisons between healthy fertile women and infertile women, and hence may be able to help women experiencing infertility to get pregnant in the future.

Do they have to take part?

Participation is entirely voluntary.
What will happen if they take part?

Endometrial NK cells, taken from non-pregnant womb will be mixed with white blood cells or chemicals derived from the sperm of an anonymous donor in a laboratory. Scientists will check if any of the cells or chemicals changes the appearance or behaviour of fertile women’s endometrial NK cells that could indicate that they became uterine NK cells during the experiment. It is important to note that no embryos or stem cells can be generated during these experiments. The endometrial NK cells can only survive for a very short period outside the body and will be discarded at the end of the observation period.

What do women have to do?

During the sterilisation, it will be necessary to visualise the neck of the womb (the cervix), and an instrument will be inserted into the neck of the womb to enable us to move the womb slightly to access the fallopian tubes more easily from above. At this stage of the procedure we would like to insert a fine biopsy sampler through the neck of the womb to allow us to sample the cells from the lining if the womb. It is a little like having a cervical smear taken. This will be done whilst women are under anaesthetic and will take no longer than a couple of minutes.

What are the side effects of taking part?

Women will not experience any pain. There is a very small chance that there will be a small amount of bleeding afterwards, it will be minimal and will resolve in a day or two. While they may experience some complications as a result of their original operation participating in this study will not, in any way, contribute to these.

What are the benefits of taking part?

By taking part women will allow us to establish whether the presence of male white blood cells or chemicals in the sperm has an effect on endometrial NK cells. If such an effect can be shown, it may help us to improve the treatment of women experiencing various problems during their pregnancies in the long run. This however, is a long term goal that will require the participation of hundreds of couples in the future. There is no direct benefit to women in taking part.

What happens if something goes wrong?

As mentioned before, any problems patients may experience will be related to the treatment they are going under originally and not to the fact that we are removing cells from the uterus. Regardless of this, if they wish to complain about any aspect of the way they may have been approached or treated during the course of this study, the normal National Health Service complaints mechanisms should be available to them.

What will happen to the results of the research study?

The results will be published in international research journals. At this point only statistical data will be presented. There will be no way that any patient could be identified as an individual. Also the findings will be used in applications for further research funding.

 

 

Follow The Fertility Clinic On FacebookFollow The Fertility Clinic On TwitterFollow The Fertility Clinic On Google

Arrange an appointment with us

Contact Jemma Hand to arrange an appointment with one of our fertility specialists.

call the fertility clinic

 

Telephone +44 (0)800 689 1317

Telephone +44 (0)7860 439346
Email admin@thefertilityclinic.org.uk

Fertility Clinics

Liverpool Fertility Clinic
Spire Murrayfield Hospital
Holmwood Drive
Wirral. CH61 1AU

London Fertility Clinic
No10 Harley Street
London. W1G 9PF

Women have trusted The Fertility Clinic

 

Dr Gazvani on City Talk

I can't get pregnant ?

why can i not get pregnant

We Will Tell You ?

 

Read More...

The Fertility Clinic Latest News (2)

  • 1
  • 2
Prev Next

Scientists hail 'amazing discovery' as it's revealed infertile mothers who use donor eggs DO pass their DNA to their children

Infertile women forced to use donor eggs still pass their DNA to their child The 'amazing discovery' was made by scientists at a Spanish fertility clinic Had been thought fertilised egg only...

Read more

Egg Donation a Thriving Business

Pretoria - More and more families affected by fertility problems have turned to egg donations as their preferred option of having children, saying they not only give them the chance...

Read more

We Want a Boy: The Ethics of Sex Selection in the Clinic

Controversy is no rarity in the field of reproductive endocrinology and infertility. Since its discovery and early clinical applications, everyone seemed to have (and still has) an opinion about in...

Read more

Why it’s wrong to ban anonymity for egg and sperm donors

‘Both donors and recipients should be allowed opt for either anonymous or identifiable donation as they see fit. In short, I am for choice’ The central pillar of the Children and...

Read more

The best physicians in the field of infertility and egg donation come to Charleston to discuss high-tech advancements

One of the most important medical conferences in North America focusing on the field of Infertility Medicine is being hosted by Charleston’s own Coastal Fertility Specialists, March 5 – 8...

Read more

Egg Freezing Seminar Allows Women to Pause the Biological Clock for Age, Social or Medical Reasons

Atlanta Center for Reproductive Medicine invites women to attend a discussion and social gathering on March 30 to learn more about egg freezing. Build your family when the time is...

Read more

She’s just not that into you: China’s bachelors in crisis thanks to shortage of women

CHINA’s bachelors are in crisis. There just aren’t enough women to go around. Figures released this month show that at the end of 2014, China had 701 million men and...

Read more

Couple uses IVF to have baby girl, raising questions on ethics of sex selection

Ever heard of “gender disappointment”? Jayne and Jon Cornwill certainly have. It’s what drove the Australian couple to mortgage their house, fly to California, and cough up nearly $50,000 to...

Read more

Google++ Lets You Select Your Own Gender

Unity in diversity – I suppose that is where the word “university” comes from, where every element is an individual, and yet on the collective whole, it makes up a...

Read more

Sexual ‘rights’? I do not think that word means what you think it means.

When abortion activists came out shrieking with rage at Canadian Member of Parliament Stephen Woodworth’s suggestion that a committee examine human life in the womb in 2013, he was somewhat...

Read more

Gender selection: Australian couple spent $50,000 and travelled to US to have baby girl

Couple sought out gender selection treatment, which is illegal in Australia, after having three boys With three sons already, Jayne Cornwill and her husband Jon were intent on having a baby...

Read more

The $50,000 Daughter

The cost of the "perfect family" is steep, financially and morally. From the time she was a small girl, Jayne Cornwill wanted to be a mom. That sounds sweet, but wait for...

Read more

The Facts About Egg Donation

For a woman who has been through a number of failed IVF cycles, egg donation gives new hope, while for women who are unable to provide eggs for IVF, it...

Read more

Tina Malone - This Morning 7th November 2014

After dropping almost 12 stone, with the aid of a gastric band, in order to receive the IVF treatment she was desperate for, Tina and her husband finally conceived their...

Read more

Designer babies: Should gender selection be legal?

AUSTRALIAN couples are now travelling to the United States to access fertility clinics to choose their unborn baby’s gender. While most couples are satisfied if they give birth to healthy...

Read more

One in 10 fresh IVF cycles use donated egg and sperm

One in 10 fresh IVF cycles use donated egg and sperm

One in 10 fresh IVF cycles used donated fertilised eggs or embryos, and a third of all patients were single or had registered with a female partner, reveal the latest...

Read more

Rapid Fertility Access

The Fertility Clinic Rapid Fertility Access

Lets Get Started

 

Take The Next Step...

Choosing an IVF Centre ?

The Fertility Clinic Spire Murrayfield Hospital Wirral 2

We Will Tell You ?

 

Read More...

The Fertility Clinic Latest News

  • 1
  • 2
Prev Next

Scientists hail 'amazing discovery' as it's revealed infertile mothers who use donor eggs DO pass their DNA to their children

Infertile women forced to use donor eggs still pass their DNA to their child The 'amazing discovery' was made by scientists at a Spanish fertility clinic Had been thought fertilised egg only...

Read more

Egg Donation a Thriving Business

Pretoria - More and more families affected by fertility problems have turned to egg donations as their preferred option of having children, saying they not only give them the chance...

Read more

We Want a Boy: The Ethics of Sex Selection in the Clinic

Controversy is no rarity in the field of reproductive endocrinology and infertility. Since its discovery and early clinical applications, everyone seemed to have (and still has) an opinion about in...

Read more

Why it’s wrong to ban anonymity for egg and sperm donors

‘Both donors and recipients should be allowed opt for either anonymous or identifiable donation as they see fit. In short, I am for choice’ The central pillar of the Children and...

Read more

The best physicians in the field of infertility and egg donation come to Charleston to discuss high-tech advancements

One of the most important medical conferences in North America focusing on the field of Infertility Medicine is being hosted by Charleston’s own Coastal Fertility Specialists, March 5 – 8...

Read more

Egg Freezing Seminar Allows Women to Pause the Biological Clock for Age, Social or Medical Reasons

Atlanta Center for Reproductive Medicine invites women to attend a discussion and social gathering on March 30 to learn more about egg freezing. Build your family when the time is...

Read more

She’s just not that into you: China’s bachelors in crisis thanks to shortage of women

CHINA’s bachelors are in crisis. There just aren’t enough women to go around. Figures released this month show that at the end of 2014, China had 701 million men and...

Read more

Couple uses IVF to have baby girl, raising questions on ethics of sex selection

Ever heard of “gender disappointment”? Jayne and Jon Cornwill certainly have. It’s what drove the Australian couple to mortgage their house, fly to California, and cough up nearly $50,000 to...

Read more

Google++ Lets You Select Your Own Gender

Unity in diversity – I suppose that is where the word “university” comes from, where every element is an individual, and yet on the collective whole, it makes up a...

Read more

Sexual ‘rights’? I do not think that word means what you think it means.

When abortion activists came out shrieking with rage at Canadian Member of Parliament Stephen Woodworth’s suggestion that a committee examine human life in the womb in 2013, he was somewhat...

Read more

Gender selection: Australian couple spent $50,000 and travelled to US to have baby girl

Couple sought out gender selection treatment, which is illegal in Australia, after having three boys With three sons already, Jayne Cornwill and her husband Jon were intent on having a baby...

Read more

The $50,000 Daughter

The cost of the "perfect family" is steep, financially and morally. From the time she was a small girl, Jayne Cornwill wanted to be a mom. That sounds sweet, but wait for...

Read more

The Facts About Egg Donation

For a woman who has been through a number of failed IVF cycles, egg donation gives new hope, while for women who are unable to provide eggs for IVF, it...

Read more

Tina Malone - This Morning 7th November 2014

After dropping almost 12 stone, with the aid of a gastric band, in order to receive the IVF treatment she was desperate for, Tina and her husband finally conceived their...

Read more

Designer babies: Should gender selection be legal?

AUSTRALIAN couples are now travelling to the United States to access fertility clinics to choose their unborn baby’s gender. While most couples are satisfied if they give birth to healthy...

Read more

One in 10 fresh IVF cycles use donated egg and sperm

One in 10 fresh IVF cycles use donated egg and sperm

One in 10 fresh IVF cycles used donated fertilised eggs or embryos, and a third of all patients were single or had registered with a female partner, reveal the latest...

Read more

TheFertilityClinicLogo2

Liverpool Fertility Clinic - Spire Murrayfield Hospital, Holmwood Drive, Wirral. CH61 1AU

London Fertility Clinic - No10 Harley Street, London, W1G 9PF

Telephone : +44 (0)800 689 1317 Mobile : +44 (0)7860 439346

Follow The Fertility Clinic On FacebookFollow The Fertility Clinic On TwitterFollow The Fertility Clinic On Google

 

crown logo small

 

Copyright © 2014. The Fertility Clinic All Rights Reserved.